Born into a noble family in Naples, de Curtis was the firstborn of the fresco painter Giuseppe de Curtis and his wife, Elisabetta Minnon, and was a great-grandson of composer Saverio Mercadante. He expressed his first interest in painting, which he learned from his father, and which he perfected to the point that he was called a "contemporary Salvator Rosa". He was a complete artist, writing poetry and theatrical works as well as verses for popular songs; he was also a sculptor. His love for Neapolitan song led him to collaborate with composer Vincenzo Valente, at the time a lodger at the de Curtis family palace in corso Garibaldi. It was, in fact, Valente who in 1889 set to music his first song, "A Pacchianella"; the following year, he set another of de Curtis's texts, "Muglierema come fa?". "'I Pazziava" followed in 1890, and "Ninuccia" in 1894; "Tiempe Felice" came in 1895. De Curtis never stopped writing songs and poems; it seems, however, to have never been much more for him than a way to pass the time.